Prostate cancer case presentation ppt

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Endocrine cancer ppt. Disfunctiile endocrine - cauze, simptome si tratament - Donna Medical Center

AtomistilorCom. Magurele, jud. Ilfov, C. MG-6, cod"— Presentation transcript: 1 Str. MG-6, cod tel. Dana Niculae Dr. Valeria Lungu Dr. Atomistilor nr.

Targeting Cancer- GP Education Case Study 2 Prostate Cancer

Consecintele metastazelor osoase sunt adesea devastatoare. Astfel, metastazele osteolitice pot cauza dureri severe, fracturi patologice, hipercalcemie cronica, compresie spinala sau alt sindrom de compresie a sistemului nervos.

Metastazele osteoblastice prostate cancer case presentation ppt, de asemenea, dureri osoase si fracturi patologice cauzate de calitatea slaba a tesutului osos produs de osteoblaste [2]. Mai mult, cancerul este in general incurabil atunci cand tumora primara metastazeaza in os: numai 20 de procente din pacientele cu cancer de san supravietuiesc 5 ani de la descoperirea metastazelor osoase [3].

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Introduction Bone metastases are frequent complication of cancer occurring up to 70 percent of patients with advanced breast or prostate cancer [1] and in approximatively 15 to 30 percent of patients with carcinoma of the lung, colon, stomach, bladder, uterus, rectum, thyroid or kidney. The consequences of bone metastasis are often devastating.

Osteolytic metastases can cause severe pain, pathologic fracture, life-threatening hypercalcemia, spinal cord compression and other nerve-compression syndromes.

Patients with osteoblastic metastases have bone pain and pathologic fractures because of poor quality of bone produced by the osteoblasts [2]. Furthermore once tumors metastasize to bone they are usually incurable: only 20 percent of patients with breast cancer are still alive five years after the discovery of bone metastases [3].

This classification actually represents two extremes of a continuum in which dysregulation of the normal bone remodeling process occurs Figure 1.

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Patients can have both osteolytic and osteoblastic metastasis or mixed lesions containing both elements [2]. Several factors account for the frequency of bone metastasis. Blood flow is high in areas of red marrow [4], accounting for the predilection of metastases for those sites.

Furthermore, tumor cells produce adhesive molecules that bind them to marrow stormal cells and bone matrix.

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Metastazele au fost pin cu prostatita ca fiind osteolitice sau osteoblastice.

Aceasta clasificare reprezinta de fapt extremele situatiilor reale in care intervine o alterare a procesului de remodelare osoasa Figura 1.

Gastric cancer ppt Încărcat de Beuran Preoperative measured internal pelvimetry and rectal cancer surgery results - is there a real link? February European Journal of Surgical Oncology - Surgical site infection after gastrointestinal surgery in high-income, middle-income, and lowincome countries : A prospective, international, multicentre cohort study - February The Lancet Infectious Diseases Matei Bratu Bogdan Balmes Bogdan Diaconescu Mircea Beuran - Se transmite condilom Rare Case of Intestinal Obstruction in an Elderly Woman, July Chirurgia Bucharest, Romania : - GlobalSurg 2 collaborative: Determining gastric cancer ppt worldwide epidemiology of surgical site infections after gastrointestinal surgery -- A multicenter, international study ongoing data collection stage "Anatomical landmarks in laparoscopic surgical treatment of hiatal hernias" M. Bratu, B.

Pacientii pot prezenta atat metastaze osteolitice sau osteoblastice cat si leziuni mixte continand ambele elemente [2]. Mai multi factori sunt raspunzatori pentru frecventa ridicata a metastazelor osoase.

Fluxul sanguin crescut prezent la nivelul maduvei rosii [4] este raspunzator pentru predilectia localizarii metastazelor in aceste zone. Tesutul osos depoziteaza, de asemenea, factori de crestere imobilizati, proteine morfogenetice si calciu [5].

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Remo- delarea sistemului osos adult, se realizeaza continuu, prin activitatea coordonata a osteoclastelor si osteoblastelor la suprafata trabeculara si sistemului harvesian. In tesutul normal acest proces de remodelare se desfasoara dupa secventa: osteoclastele resorb tesutul urmand ca osteoclastele sa-l reformeze, in aceeasi zona Figura 2.

Fig 2 Procesele de resorbtie A si formare B a tesutului osos Bone resorption A and bone formation B processes Bone is also a large repository for immobilized growth factors, bone morphogenetic proteins and calcium [5]. The adult skeleton continually turns over and remodels itself through the coordinated activity of osteoclasts and osteoblasts on trabecular surfaces and the harvesian system.

In normal bone there is a balanced remodeling sequence: first osteoclasts resorb bone, and than osteoblasts form bone at the same site Figure 2.

Utilizarea fluorului este limitata de energia sa înalta iar a strontiului de captarea lenta si dezintegrarea rapida. Primii agenti ai Tcm utilizati in scintigrafia osoasa au fost polifosfatii.

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Susceptibiliatea ca legatura P-O-P sa fie atacata de enzimele fosfataze, a condus la dezvoltarea fosfonatilor continand o legatura P-C-P, cel mai performant reprezentant al acestei clase fiind MDP acidul metilendifosfonic. Mecanismul captarii difosfonaţilor, in special a MDP, cu o structura posibila de tipul: [Tc MDP OH ]n- se bazeaza pe potrivirea spatiilor dintre atomii O- donori din MDP cu spatiile dintre ionii de Ca din cristalele de hidroxiapatita 3,44 A cu structura de tipul: [3Ca3 PO4 2Ca OH 2] Studiile autoradiografice au aratat ca legarea fosfonatilor la suprafata cristalului osos pare a fi ireversibila, compusul fiind incorporat in structura cristalului.

Bone metastases imaging and therapy Inorganic ions were the first materials to be used in bone imaging because of the known mineral exchange processes in bone.

Fluorine use is limited by high energy, strontium by slow uptake and rapid decay. The first technetium agents used were the polyphosphates, but these proved less than ideal because of the susceptibility of the P-O-P link to attack by phosphatase enzymes.

Development of the phosphonates containing a P-C-P link resolved this problem. The most important compound of this class is MDP methylenediphosphonic acid. Phosphonates can form monomeric and polymeric species around the Me IV core, up to 11 molecular species with different molecular weights have been identified by HPLC.

Complexes formed around Me V core MW — d shows best ratio between bone uptake and urine clearance.

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The prelevance of metastatic bone disease in all countries, both developed and developing, creates a large demand for new therapeutic and palliative agents. A great interest for radiotherapy of skeletal metastases is represented by phosphonic acid chelates labeled with β-emitting therapeutic radionuclides such prostate cancer case presentation ppt ,Re, Sm, Lu, Ho [6,7].

These studies highlight the interdependency between chemical structure of the ligand and biologic behavior biodistribution of the labelled phosphonates.

Coordonatorstintific :Dr Bogdan Streza medic primar chirurg urolog 2. Analiza statistica a Sectiei deUrologie Spitalul Clinic CF 2 Bucuresti Intre anii au fost internatiunnumar dede bolnavidiagnosticati cu Adenocarcinom de prostata. Cercetari recente arata ca. Principalul factor de stil de viata raspunzator de frecventa mare a cancerului de prostata este alimentatia bogata in grasimi animale si carne si saraca in fructe si vegetale Martin D Albeloff-Clinical Oncology a 3-a editie p.

Frecventa metastazelor osoase, atat in tarile dezvoltate cat si in cele in curs de dezvoltare, a dus la experimentarea si testarea de noi agenti terapeutici si paleativi.

De mare interes in radioterapia metastazelor osoase sunt chelatii acizilor fosfonici radiomarcati cu β-emitatori terapeutici, precum ,Re, Sm, Lu, Ho [6,7]. Caracteristicile fizice a acestor radonuclizi sunt prezentate in tabelul de mai jos.

Pe aceasta baza, radiofarmaceuticele destinate marcarii cu 99mTc, in scop imagistic, au fost marcate cu Re si testate ca agenti terapeutici []. The chemical properties of rhenium are similar to technetium. Hence, rhenium analogues of technetium radiopharmaceuticals have been prepared and explored as therapeutic agents [].

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Its favorable nuclear parameters, i. Reniuhidroxietiliden difosfonatul Re-HEDP este un nou radiofarmaceutic, cu localizare preferentiala la nivelul metastazelor osoase, depozitand local o radiatie beta eficienta terapeutic. Procesul de marcare al HEDP cu Re este caracterizat de: raportul molar dintre metal si agentul reducator, pH, temperatura si mediul de reactie. The radiolabeled phosphonate are stable in vitro up to 24h, under the optimal conditions described earlier.

Captarea osoasa creste de la Testele de biodistributie au fost efectuate pe prostate cancer case presentation ppt animale. The bone uptake was increasing from Biodistribution profile was tested on animal models.

Organ Fig. Raspunsul la tratament apare in primele 5 zile [5].

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